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A7002958

Cefazolin , 10mMinDMSO , 25953-19-9

Synonym(s):
Cefazolin;Cephazolin;CFZ

CAS NO.:25953-19-9

Empirical Formula: C14H14N8O4S3

Molecular Weight: 454.51

MDL number: MFCD00243010

EINECS: 247-362-8

Pack Size Price Stock Quantity
1ml RMB399.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 198-200 C
Density  2.01±0.1 g/cm3(Predicted)
storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility  DMSO (Slightly), Methanol (Very Slightly, Heated)
pka pKa 2.15 (Uncertain)
form  Solid
color  White to Off-White
Stability: Hygroscopic
CAS DataBase Reference 25953-19-9(CAS DataBase Reference)

Description and Uses

Cefazolin has the natural acetyl side chain at C-3 replaced by a thio-linked thiadiazole ring. Although this group is an activating leaving group, the moiety is not subject to the inactivating host hydrolysis reaction that characterizes cephapirin. At C-7, it possesses a tetrazoylmethylene unit. Cefazolin is less irritating on injection than its cohort in this generation of drugs and has a longer half-life than cephapirin. Its dosing should be reduced in the presence of renal impairment. It is comparatively unstable and should be protected from heat and light.

Cefazolin is an antibacterial compound derived from 7-amino-cephalosporanic acid.

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P280-P284-P304+P340-P342+P311
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  2941906000
Hazardous Substances Data 25953-19-9(Hazardous Substances Data)
Toxicity mouse,LD50,intramuscular,4gm/kg (4000mg/kg),Byoin Yakugaku. Hospital Pharmacology. Vol. 3, Pg. 220, 1978.

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