Cefazolin , 10mMinDMSO , 25953-19-9
Synonym(s):
Cefazolin;Cephazolin;CFZ
CAS NO.：25953-19-9
Empirical Formula: C14H14N8O4S3
Molecular Weight: 454.51
MDL number: MFCD00243010
EINECS: 247-362-8
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB399.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 198-200 C |
| Density | 2.01±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Very Slightly, Heated) |
| form | Solid |
| pka | pKa 2.15 (Uncertain) |
| color | White to Off-White |
| Stability: | Hygroscopic |
Description and Uses
Cefazolin has the natural acetyl side chain at C-3 replaced by a thio-linked thiadiazole ring. Although this group is an activating leaving group, the moiety is not subject to the inactivating host hydrolysis reaction that characterizes cephapirin. At C-7, it possesses a tetrazoylmethylene unit. Cefazolin is less irritating on injection than its cohort in this generation of drugs and has a longer half-life than cephapirin. Its dosing should be reduced in the presence of renal impairment. It is comparatively unstable and should be protected from heat and light.
Cefazolin is an antibacterial compound derived from 7-amino-cephalosporanic acid.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H317-H334 |
| Precautionary statements | P261-P280-P284-P304+P340-P342+P311 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 2941906000 |
| Toxicity | mouse,LD50,intramuscular,4gm/kg (4000mg/kg),Byoin Yakugaku. Hospital Pharmacology. Vol. 3, Pg. 220, 1978. |
