Home Categories API 4-Acetamidophenol
A0637712

4-Acetamidophenol , CP,>98.0%(HPLC) , 103-90-2

Synonym(s):
Paracetamol;Acetaminophen;APAP;4-Acetamidophenol;N-(4-Hydroxyphenyl)acetamide

CAS NO.:103-90-2

Empirical Formula: C8H9NO2

Molecular Weight: 151.16

MDL number: MFCD00002328

EINECS: 203-157-5

Pack Size Price Stock Quantity
25G RMB23.20 In Stock
100G RMB52.00 In Stock
500G RMB198.40 In Stock
2.5kg RMB559.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 168-172 °C(lit.)
Boiling point: 273.17°C (rough estimate)
Density  1,293 g/cm3
vapor pressure  0.008Pa at 25℃
refractive index  1.5810 (rough estimate)
Flash point: 11 °C
storage temp.  Inert atmosphere,Room Temperature
solubility  ethanol: soluble0.5M, clear, colorless
form  Crystals or Crystalline Powder
pka 9.86±0.13(Predicted)
color  White
PH 5.5-6.5 (H2O, 20℃)(saturated solution)
PH Range 5.5 - 6.5 (H?O, 20 °C) (saturated solution)
Odor odorless
explosive limit 15%(V)
Water Solubility  14 g/L (20 ºC)
Merck  14,47
BRN  2208089
BCS Class 3,4
InChIKey RZVAJINKPMORJF-UHFFFAOYSA-N
LogP 1.098 at 25℃

Description and Uses

Acetaminophen is an analgesic and antipyretic compound. Unlike many NSAIDs, which inhibit both COX-1 and COX-2, early studies suggested that acetaminophen is a poor inhibitor of both isoforms. However, it does inhibit COX-2 by 83% and COX-1 by 56% in human blood ex vivo, albeit at a high 1,000 mg dose, with IC50 values of 25.8 and 113.7 μM, respectively. Acetaminophen is enzymatically and non-enzymatically converted to several reactive metabolites that contribute to adverse or indirect effects, including liver injury. At toxic doses, the acetaminophen metabolite N-acetyl-4-benzoquinone imine (NAPQI; ) depletes glutathione reserves in the liver, leading to an accumulation of NAPQI and subsequent hepatocyte necrosis. Acetaminophen decreases glutathione levels and reduces glutathione peroxidase activity in mice when administered at a dose of 250 mg/kg and induces ferroptotic cell death in primary mouse hepatocytes, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 . Acetaminophen has analgesic and antipyretic properties in animal models.

manufacture of azo dyes, photographic chemicals.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn,T,F
Risk Statements  22-36/37/38-52/53-36/38-40-39/23/24/25-23/24/25-11
Safety Statements  26-36-61-37/39-22-45-36/37-16-7
RIDADR  UN 3077 9/PG III
WGK Germany  1
RTECS  AE4200000
Autoignition Temperature 540 °C
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29242930
Toxicity LD50 in mice (mg/kg): 338 orally (Starmer), 500 i.p. (Dahlin, Nelson)

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