A6999758
Demeclocyclinehydrochloride , 10mMinDMSO , 64-73-3
Synonym(s):
7-Chloro-6-demethyltetracycline hydrochloride;Chlorodemethyltetracycline hydrochloride;Demeclocycline hydrochloride;Demethylchlorotetracycline hydrochloride
CAS NO.:64-73-3
Empirical Formula: C21H21ClN2O8.ClH
Molecular Weight: 501.32
MDL number: MFCD00864922
EINECS: 200-592-2
Pack Size | Price | Stock | Quantity |
1ml | RMB239.20 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | >245°C (dec.) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | H2O: 20 mg/mL, clear, very deep greenish yellow |
form | powder |
pka | pKa 3.3 (Uncertain) |
color | Light Yellow to Yellow |
Water Solubility | Soluble in water. |
Merck | 13,2905 |
BRN | 5705221 |
InChIKey | GVSJQNRGSCOSNJ-KBHRXELFSA-N |
CAS DataBase Reference | 64-73-3(CAS DataBase Reference) |
EPA Substance Registry System | 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)- (64-73-3) |
Description and Uses
Demeclocycline lacks the C-6-methyl of tetracycline and is produced by a genetically altered strain of Streptomyces aureofaciens. Because it is a secondary alcohol, it is more chemically stable than tetracycline against dehydration. Food and milk co-consumption decrease absorption by half, although it is 60 to 80% absorbed by fasting adults. It is the tetracycline most highly associated with phototoxicity and has been shown to produce dose-dependent, reversible diabetes insipidus with extended use.
Antibacterial;Ribosomal protein synthesis inhibitor
Safety
Symbol(GHS) | GHS07,GHS08 |
Signal word | Warning |
Hazard statements | H302+H312+H332-H315-H319-H335-H341 |
Precautionary statements | P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313 |
Hazard Codes | Xi |
Risk Statements | 43 |
Safety Statements | 36/37 |
WGK Germany | 2 |
RTECS | QI7700000 |
F | 8-10-21 |
HS Code | 29413020 |
Toxicity | LD50 orally in rats: 2372 mg/kg (Goldenthal) |