5-Bromo-2′-deoxyuridine , 10mMinDMSO , 59-14-3
Synonym(s):
brdu;5-BrdU;5-Bromo-1-(2-deoxy-β-D -ribofuranosyl)uracil;5-Bromo-2′-deoxyuridine;5-Bromouracil deoxyriboside
CAS NO.：59-14-3
Empirical Formula: C9H11BrN2O5
Molecular Weight: 307.1
MDL number: MFCD00006529
EINECS: 200-415-9
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 191-194 °C (dec.)(lit.) |
| alpha | 31 º (c=1, 0.1N NaOH) |
| Density | 1.8573 (rough estimate) |
| refractive index | 22 ° (C=1, H2O) |
| storage temp. | -20°C |
| solubility | NH4OH: 0.1 M at 20 °C, clear, colorless |
| pka | 7.73±0.10(Predicted) |
| form | Crystals or Crystalline Powder |
| color | White to yellow |
| Water Solubility | 1-5 g/100 mL at 22 ºC |
| Merck | 14,1452 |
| BRN | 30395 |
| Stability: | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | XMJRLEURHMTTRX-UHFFFAOYSA-N |
| LogP | -0.290 |
| CAS DataBase Reference | 59-14-3(CAS DataBase Reference) |
| EPA Substance Registry System | Uridine, 5-bromo-2'-deoxy- (59-14-3) |
Description and Uses
5-Bromo-2'-deoxyuridine is a nitrate reductase inhibitor that prevents the reduction of nitrate to nitrite by inhibiting the enzyme nitrate reductase. 5-Bromo-2'-deoxyuridine is a genotoxic agent that has been shown to cause DNA damage and cell death in vitro. 5-Bromo-2'-deoxyuridine also binds to NMDA receptors and may be useful as a model system for studying neurodegenerative diseases.
5-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H340-H361fd |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| Hazard Codes | Xn,T |
| Risk Statements | 68-36/37/38-63-46-24-61 |
| Safety Statements | 36/37/39-26-53-45-36 |
| WGK Germany | 2 |
| RTECS | YU7350000 |
| F | 10-23 |
| TSCA | Yes |
| HS Code | 29349990 |
| Hazardous Substances Data | 59-14-3(Hazardous Substances Data) |
