5-Bromo-2′-deoxyuridine , 10mMinDMSO , 59-14-3

Synonym(s):
brdu;5-BrdU;5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil;5-Bromo-2′-deoxyuridine;5-Bromouracil deoxyriboside

CAS NO.：59-14-3

Empirical Formula: C9H11BrN2O5

Molecular Weight: 307.1

MDL number: MFCD00006529

EINECS: 200-415-9

PRODUCT Properties

• Melting point: 191-194 °C (dec.)(lit.)
• alpha: 31 º (c=1, 0.1N NaOH)
• Density: 1.8573 (rough estimate)
• refractive index: 22 ° (C=1, H2O)
• storage temp.: -20°C
• solubility: NH₄OH: 0.1 M at 20 °C, clear, colorless
• pka: 7.73±0.10(Predicted)
• form: Crystals or Crystalline Powder
• color: White to yellow
• Water Solubility: 1-5 g/100 mL at 22 ºC
• Merck: 14,1452
• BRN: 30395
• Stability: Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
• InChIKey: XMJRLEURHMTTRX-UHFFFAOYSA-N
• LogP: -0.290

Description and Uses

5-Bromo-2'-deoxyuridine is a nitrate reductase inhibitor that prevents the reduction of nitrate to nitrite by inhibiting the enzyme nitrate reductase. 5-Bromo-2'-deoxyuridine is a genotoxic agent that has been shown to cause DNA damage and cell death in vitro. 5-Bromo-2'-deoxyuridine also binds to NMDA receptors and may be useful as a model system for studying neurodegenerative diseases.

5-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H340-H361fd
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: Xn,T
• Risk Statements: 68-36/37/38-63-46-24-61
• Safety Statements: 36/37/39-26-53-45-36
• WGK Germany: 2
• RTECS: YU7350000
• F: 10-23
• TSCA: Yes
• HS Code: 29349990