Home Categories Biochemical Engineering 2'-Deoxyuridine
A3097612

2'-Deoxyuridine , 99% , 951-78-0

Synonym(s):
1-(2-Deoxy-β-D-ribofuranosyl)uracil;Uracil deoxyriboside

CAS NO.:951-78-0

Empirical Formula: C9H12N2O5

Molecular Weight: 228.2

MDL number: MFCD00006527

EINECS: 213-455-7

Pack Size Price Stock Quantity
1G RMB39.20 In Stock
5G RMB79.20 In Stock
25G RMB383.20 In Stock
100g RMB1519.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 167-169 °C(lit.)
alpha  D22 +50° (c = 1.1 in N NaOH)
Boiling point: 370.01°C (rough estimate)
Density  1.3705 (rough estimate)
refractive index  52 ° (C=1, 1mol/L NaOH)
storage temp.  Inert atmosphere,2-8°C
solubility  DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
pka pKa 9.3(H2O t = 25) (Uncertain)
form  Powder
color  White to off-white
Water Solubility  300 g/L (20 ºC)
Sensitive  Air Sensitive
Merck  14,2910
BRN  24433
InChIKey MXHRCPNRJAMMIM-ATRFCDNQSA-N

Description and Uses

2'-Deoxyuridine is an intermediate in the synthesis of thymidylate, which is a precursor for DNA synthesis. It has been shown to inhibit the enzymatic activity of enzymes responsible for synthesizing uridine and thymidylate, leading to neuronal death. 2'-Deoxyuridine has been used as a fluorescence probe for nucleic acids and as a polymerase chain reaction (PCR) substrate. It is also known to bind with toll-like receptor 4 (TLR4), which is involved in inflammatory responses.

2'-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2'-Deoxyuridines used as labeling substrates include chloro-2'-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2'-deoxyuridine include 5-ethynyl-2'-deoxyuridine (DdU) and 5-hydroxymethyl-2'-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  36/37/38
Safety Statements  22-24/25-37/39-36/37/39-26
WGK Germany  3
RTECS  YU7490000
10-23
Hazard Note  Air Sensitive
TSCA  Yes
HS Code  29349990

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