LN-307593
PROTOVERATRINE B , 99% , 124-97-0
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 268-270°C |
| alpha | D25 -37° (pyridine); D25 -3.5° (chloroform) |
| Boiling point: | 755.18°C (rough estimate) |
| Density | 1.1826 (rough estimate) |
| refractive index | 1.6220 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 10.73±0.70(Predicted) |
Description and Uses
Also present in Veratrum album, this closely allied alkaloid may be separated from the preceding base by chromatography. It also yields colourless crystals from EtOH and is laevorotatory with [α]29D&o - 39.8° (pyridine) or - 3.5° (CHCI3). In this case, alkaline hydrolysis gives protoverine, two moles of acetic acid, one mole of (-)-2-methylbutyric acid and one mole of 2: 3-dihydroxy-2- methylbutyric acid. It may be distinguished from protoveratrine A by giving a green colour with H2S04. It also forms a complex with maleic acid having m.p. 222.2°C; [α]29D&o - 27.3°.
Safety
| Safety Statements | 22-24/25 |
| RIDADR | 1544 |
| WGK Germany | 3 |
| RTECS | FL5750000 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Toxicity | LD50 s.c. in male mice: 0.21 mg/kg (Tanaka) |
