5'-Deoxy-5-fluorouridine , >98.0%(HPLC) , 3094-09-5

Synonym(s):
5′dFUrd;5-Fluoro-5′-deoxyuridine;Doxifluridine

CAS NO.：3094-09-5

Empirical Formula: C9H11FN2O5

Molecular Weight: 246.19

MDL number: MFCD00866530

EINECS: 221-440-1

PRODUCT Properties

• Melting point: 188-192 °C(lit.)
• alpha: D25 +18.4° (c = 0.419 in water)
• Density: 1.3751 (estimate)
• refractive index: 20 ° (C=1, H2O)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 7.4(at 25℃)
• color: White
• Merck: 14,3437

Description and Uses

Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.

antineoplastic, pyrimidine antimetabolite

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317
• Precautionary statements: P261-P272-P280-P302+P352+P333+P313+P363-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 2
• RTECS: YU7526000
• Hazard Note: Irritant
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• HS Code: 29349990
• Toxicity: LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu)