Bilobalide , 10mMinDMSO , 33570-04-6
Synonym(s):
Bilobalide
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >300° |
| alpha | 57820 -64.3° (c = 2 in acetone) |
| Boiling point: | 651.7±55.0 °C(Predicted) |
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Acetone (Slightly), Methanol (Slightly) |
| pka | 11.74±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| Merck | 14,1220 |
| Stability: | Hygroscopic |
| LogP | -0.450 (est) |
| CAS DataBase Reference | 33570-04-6(CAS DataBase Reference) |
Description and Uses
Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions. It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.
Bilobalide provides protection against learning and memory impairment by reducing free radical injury and inhibiting neuronal apoptosis in the brain cortex and hippocampal CA1 region in induced vascular dementia rats.
Safety
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
| Signal word | Danger |
| Hazard statements | H302-H315-H317-H318-H410 |
| Precautionary statements | P261-P264-P270-P272-P273-P280-P301+P312+P330-P302+P352-P305+P351+P338+P310-P333+P313-P391-P501 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | LV1665000 |
| F | 10 |
| HS Code | 29322090 |
