Doripenem , 10mMinDMSO , 148016-81-3

CAS NO.：148016-81-3

Empirical Formula: C15H24N4O6S2

Molecular Weight: 420.5

MDL number: MFCD02092739

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: >186°C dec.
• Boiling point: 694.8±65.0 °C(Predicted)
• Density: 1.59±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: In water, not known, in DMSO 20 mg/ml, in pBS 3 mg/ml
• form: Solid
• pka: 4.27±0.60(Predicted)
• color: White to Light Beige
• Stability: Hygroscopic
• CAS DataBase Reference: 148016-81-3

Description and Uses

Doripenem monohydrate is an ultra-broad-spectrum injectable β-lactam antibiotic and belongs to the subgroup of carbapenems. It was introduced by Shionogi Co. of Japan under the brand name Finibax in 2005 and is being marketed outside Japan by Johnson & Johnson. Doripenem act by decreases the process of cell wall growth, which eventually leads to elimination of the infectious cell bacteria together. It is used for treatment of bacterial respiratory and urinary tract infections. Doripenem is a 1β-methyl carbapenem derivative, and it is the fourth analog to be marketed in this series following the launch of meropenem, biapenem, and ertapenem in previous years. The introduction of a 1β-methyl group to the carbapenem skeleton enhances metabolic stability to renal dehydropeptidase-1 (DHP-1) and leads to improved antibacterial potency.

Doripenem hydrate is used to treat complicated urinary infection including Pyelonephritis caused by E.coli. Doripenem hydrate is promoted in the United States as DORIBAX(R). This drug is synthesized from p-nitrobenzyl-protected enolphosphate 2b and N-(p-nitrobenzyloxycarbonyl)-protected aminomethylpyrrolidine.