Dolasetron , 10mMinDMSO , 115956-12-2

CAS NO.：115956-12-2

Empirical Formula: C19H20N2O3

Molecular Weight: 324.37

MDL number: MFCD00865542

PRODUCT Properties

• Melting point: 278 ºC
• Boiling point: 535.1±50.0 °C(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
• form: Solid
• pka: 15.36±0.30(Predicted)
• color: White
• Water Solubility: Soluble

Description and Uses

Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT₃ (K_i = 20 nM). It is selective for 5-HT₃ receptors over 5-HT_1A, 5-HT_1B, 5-HT₂, dopamine D₂, α₁-, α₂-, β-adrenergic, M_1-5 muscarinic acetylcholine, and neurokinin-1 (NK₁) receptors (IC₅₀s = >10 μM for all). Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC₅₀ = 3.8 nM). It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg. Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.

prevention and treatment of postoperative nausea and vomiting

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H302-H318
• Precautionary statements: P264-P270-P280-P301+P312-P330-P305+P351+P338-P310-P501