Capsazepine , 10mMinDMSO , 138977-28-3

Synonym(s):
Capsazepine - CAS 138977-28-3 - Calbiochem;N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide

CAS NO.：138977-28-3

Empirical Formula: C19H21ClN2O2S

Molecular Weight: 376.9

MDL number: MFCD00153778

PRODUCT Properties

• Melting point: 155-157°C
• Boiling point: 581.1±60.0 °C(Predicted)
• Density: 1.350±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: methanol: soluble
• form: solid
• pka: 9.73±0.20(Predicted)
• color: off-white
• InChIKey: DRCMAZOSEIMCHM-UHFFFAOYSA-N
• CAS DataBase Reference: 138977-28-3(CAS DataBase Reference)

Description and Uses

Transient receptor potential vanilloid type 1 (TRPV1) is a member of the transient receptor potential (TRP) family that is activated or sensitized by a variety of endogenous stimuli as a result of tissue injury and inflammation. TRPV1 is upregulated during inflammation and plays a role in the perception of pain. Capsazepine is a competitive antagonist of transient receptor potential vanilloid type 1 (TRPV1) which blocks the capsaicin-induced uptake of Ca²⁺ in neonatal rat dorsal root ganglia with an IC₅₀ of 0.42 μM and Chinese hamster ovary cells with an IC₅₀ of 17 nM. It does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1.

Capsazepine has been used as a transient receptor potential vanilloid-1 (TRPV1) antagonist:

• to study its effect on capsaicin induced extracellular signal-regulated kinase (ERK) phosphorylation
• to study the role of TRPV1 in central terminals on nociception in rats
• for functional characterization of the TRPV1 in bull spermatozoa

Safety

• Hazard statements: H402
• Precautionary statements: P273-P501
• Hazard Codes: Xn
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25-36-26
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1(a)
• PackingGroup: II