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A2460612

Capsazepine , 98% , 138977-28-3

Synonym(s):
Capsazepine - CAS 138977-28-3 - Calbiochem;N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide

CAS NO.:138977-28-3

Empirical Formula: C19H21ClN2O2S

Molecular Weight: 376.9

MDL number: MFCD00153778

Pack Size Price Stock Quantity
10MG RMB530.40 In Stock
50MG RMB1898.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 155-157°C
Boiling point: 581.1±60.0 °C(Predicted)
Density  1.350±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  methanol: soluble
form  solid
pka 9.73±0.20(Predicted)
color  off-white
InChIKey DRCMAZOSEIMCHM-UHFFFAOYSA-N

Description and Uses

Transient receptor potential vanilloid type 1 (TRPV1) is a member of the transient receptor potential (TRP) family that is activated or sensitized by a variety of endogenous stimuli as a result of tissue injury and inflammation. TRPV1 is upregulated during inflammation and plays a role in the perception of pain. Capsazepine is a competitive antagonist of transient receptor potential vanilloid type 1 (TRPV1) which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia with an IC50 of 0.42 μM and Chinese hamster ovary cells with an IC50 of 17 nM. It does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1.

Capsazepine has been used as a transient receptor potential vanilloid-1 (TRPV1) antagonist:

  • to study its effect on capsaicin induced extracellular signal-regulated kinase (ERK) phosphorylation
  • to study the role of TRPV1 in central terminals on nociception in rats
  • for functional characterization of the TRPV1 in bull spermatozoa

Safety

Hazard statements  H402
Precautionary statements  P273-P501
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  22-24/25-36-26
RIDADR  2811
WGK Germany  3
HazardClass  6.1(a)
PackingGroup  II

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