Pentostatin , 98%(HPLC) , 53910-25-1
Synonym(s):
(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol;2ʹ-Deoxycoformycin, (8R)-3-(2-deoxy-β-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Pentostatin, S. antibioticus;2′-dCF;DCF;Deoxycoformycin
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB439.20 | In Stock |
|
| 25MG | RMB2020.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 154-157?C |
| alpha | D25 +76.4° (c = 1 in water); D23 +73.0° (c = 1, pH 7 buffer) |
| Boiling point: | 411.43°C (rough estimate) |
| Density | 1.2576 (rough estimate) |
| refractive index | 1.6081 (estimate) |
| storage temp. | -20°C |
| solubility | H2O: soluble10mg/mL, clear |
| pka | 5.2(at 25℃) |
| form | White solid |
| color | white to beige |
| optical activity | [α]/D +70 to +80°, c = 1 in H2O |
Description and Uses
Pentostatin, an adenosine deaminase inhibitor, is an orphan drug introduced for the treatment of hairy cell leukemia. The agent is considered a significant advance over alpha-interferon, the only other drug available for this indication. The majority of patients treated with pentostatin have been reported to remain in remission for at least four years. It is also under investigation for the treatment of other kinds of leukemia and in transplant rejection.
Pentostatin is a potent antitumor antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumor agent.
