Phenothiazine , 98% , 92-84-2

Synonym(s):
10H-Phenothiazine;Phenothiazine;PTZ

CAS NO.：92-84-2

Empirical Formula: C12H9NS

Molecular Weight: 199.27

MDL number: MFCD00005015

EINECS: 202-196-5

PRODUCT Properties

• Melting point: 184 °C
• Boiling point: 371 °C(lit.)
• Density: 1.362
• vapor pressure: 0.0000647 Pa (20 °C)
• refractive index: 1.6353
• Flash point: 202°C
• storage temp.: Store below +30°C.
• solubility: 0.127mg/l
• form: Prills or Beads
• pka: pKa 2.52 (Uncertain)
• color: Yellow
• PH: 6 (10g/l, H2O, 20℃)(aqueous suspension)
• Water Solubility: 2 mg/L (25 ºC)
• Sensitive: Light Sensitive
• Merck: 14,7252
• BRN: 143237
• Exposure limits: ACGIH: TWA 5 mg/m3 (Skin); NIOSH: TWA 5 mg/m3
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. May discolour upon exposure to light.
• InChIKey: WJFKNYWRSNBZNX-UHFFFAOYSA-N
• LogP: 3.78 at 25℃

Description and Uses

Phenothiazine was initially synthesized in 1883 by Bernthsen. It was the basis for the development of other drugs including the phenothiazine class of antipsychotics or neuroleptics. Phenothiazines are the largest class of neuroleptics and include agents such as chlorpromazine, thioridazine, and prochlorperazine. In 1933, a derivative of phenothiazine, promethazine, was synthesized. It was found to have much more significant sedative and antihistaminic effects than previous derivatives of phenothiazine and it was used to induce sedation for surgical patients. After promethazine was developed, a series of agents, including chlorpromazine, was synthesized and tested in France at a military hospital by the French physician Laborit. Laborit found that chlorpromazine induced calm in patients and had other effects that might be useful clinically. Chlorpromazine, known colloquially as ‘Laborit’s drug’ was released into the market in 1953 after a trial published in 1952 showed efficacy in treatment of psychosis in 38 individuals who received daily injections of chlorpromazine. Chlorpromazine is the prototypical drug for the phenothiazine class of antipsychotics. The phenothiazines are classified as low-potency antipsychotics and have more side effects at standard doses than the newer agents used as neuroleptics. For example, they are more anticholinergic and have more extrapyramidal effect than newer agents.

A key component of antipsychotic and antihistaminic drugs.

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Warning
• Hazard statements: H302-H317-H373-H410
• Precautionary statements: P260-P273-P280-P301+P312-P302+P352-P314
• Hazard Codes: Xi,N,Xn
• Risk Statements: 36/37/38-43-51/53-36/38-40-20/21/22-52/53-48/22-22
• Safety Statements: 26-36-61-36/37/39-29-22-36/37
• OEB: B
• OEL: TWA: 5 mg/m3 [skin]
• WGK Germany: 1
• RTECS: SN5075000
• F: 8-23
• Autoignition Temperature: 470 °C
• TSCA: Yes
• HS Code: 29343090
• Toxicity: LD50 orally in Rabbit: > 2000 mg/kg