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A6682612

Phenothiazine , 98% , 92-84-2

Synonym(s):
10H-Phenothiazine;Phenothiazine;PTZ

CAS NO.:92-84-2

Empirical Formula: C12H9NS

Molecular Weight: 199.27

MDL number: MFCD00005015

EINECS: 202-196-5

Pack Size Price Stock Quantity
100G RMB38.40 In Stock
500G RMB116.00 In Stock
2.5kg RMB559.20 In Stock
5KG RMB959.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 184 °C
Boiling point: 371 °C(lit.)
Density  1.362
vapor pressure  0.0000647 Pa (20 °C)
refractive index  1.6353
Flash point: 202°C
storage temp.  Store below +30°C.
solubility  0.127mg/l
form  Prills or Beads
pka pKa 2.52 (Uncertain)
color  Yellow
PH 6 (10g/l, H2O, 20℃)(aqueous suspension)
Water Solubility  2 mg/L (25 ºC)
Sensitive  Light Sensitive
Merck  14,7252
BRN  143237
Exposure limits ACGIH: TWA 5 mg/m3 (Skin)
NIOSH: TWA 5 mg/m3
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. May discolour upon exposure to light.
InChIKey WJFKNYWRSNBZNX-UHFFFAOYSA-N
LogP 3.78 at 25℃

Description and Uses

Phenothiazine was initially synthesized in 1883 by Bernthsen. It was the basis for the development of other drugs including the phenothiazine class of antipsychotics or neuroleptics. Phenothiazines are the largest class of neuroleptics and include agents such as chlorpromazine, thioridazine, and prochlorperazine. In 1933, a derivative of phenothiazine, promethazine, was synthesized. It was found to have much more significant sedative and antihistaminic effects than previous derivatives of phenothiazine and it was used to induce sedation for surgical patients. After promethazine was developed, a series of agents, including chlorpromazine, was synthesized and tested in France at a military hospital by the French physician Laborit. Laborit found that chlorpromazine induced calm in patients and had other effects that might be useful clinically. Chlorpromazine, known colloquially as ‘Laborit’s drug’ was released into the market in 1953 after a trial published in 1952 showed efficacy in treatment of psychosis in 38 individuals who received daily injections of chlorpromazine. Chlorpromazine is the prototypical drug for the phenothiazine class of antipsychotics. The phenothiazines are classified as low-potency antipsychotics and have more side effects at standard doses than the newer agents used as neuroleptics. For example, they are more anticholinergic and have more extrapyramidal effect than newer agents.

A key component of antipsychotic and antihistaminic drugs.

Safety

Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Warning
Hazard statements  H302-H317-H373-H410
Precautionary statements  P260-P273-P280-P301+P312-P302+P352-P314
Hazard Codes  Xi,N,Xn
Risk Statements  36/37/38-43-51/53-36/38-40-20/21/22-52/53-48/22-22
Safety Statements  26-36-61-36/37/39-29-22-36/37
OEB B
OEL TWA: 5 mg/m3 [skin]
WGK Germany  1
RTECS  SN5075000
8-23
Autoignition Temperature 470 °C
TSCA  Yes
HS Code  29343090
Toxicity LD50 orally in Rabbit: > 2000 mg/kg

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