Pentagastrin , ≥95%(HPLC) , 5534-95-2
Synonym(s):
N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide
CAS NO.：5534-95-2
Empirical Formula: C37H49N7O9S
Molecular Weight: 767.9
MDL number: MFCD00076515
EINECS: 226-889-7
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB896.00 | In Stock |
|
| 100MG | RMB2446.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 229-230° (dec) |
| alpha | D22 -28.8 ±0.5° (DMF) |
| Boiling point: | 1196.6±65.0 °C(Predicted) |
| Density | 1.303±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Practically insoluble in water; soluble in 5M ammonia and in dimethylformamide; slightly soluble in ethanol (96%). |
| form | powder |
| pka | 4.19±0.10(Predicted) |
| color | White to off-white |
| Sequence | N-t-Boc-β-Ala-Trp-Met-Asp-Phe-NH2 |
| InChIKey | NEYNJQRKHLUJRU-DZUOILHNSA-N |
| SMILES | C(C1=CNC2C=CC=CC1=2)[C@H](NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N)CC1C=CC=CC=1 |&1:10,27,35,43,r| |
Description and Uses
Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist. It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM). Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM). It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively). Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.
anesthetic (local)
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Hazard Codes | T |
| Risk Statements | 61-36/38-20/21 |
| Safety Statements | 53-45-36/37/39-22 |
| WGK Germany | 1 |
| RTECS | AY2970000 |
| Hazardous Substances Data | 5534-95-2(Hazardous Substances Data) |
