Sucralfate , USP , 54182-58-0

Synonym(s):
Sucralfate;Sucrose octasulfate–aluminum complex

CAS NO.：54182-58-0

Empirical Formula: C11H52Al16O75S8-16

Molecular Weight: 2072.71

MDL number: MFCD00145339

EINECS: 259-018-4

PRODUCT Properties

• Melting point: >220°C (dec.)
• Boiling point: 1990℃ at 101.325kPa
• Density: 0.338 at 20℃
• vapor pressure: 0Pa at 25℃
• storage temp.: Inert atmosphere,2-8°C
• solubility: Practically insoluble in water, in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of mineral acids and alkali hydroxides.
• pka: pKa = 0.43 to 1.19(at 25℃)
• form: Solid
• color: White
• LogP: 1.46 at 25℃ and pH7

Description and Uses

Sucralfate is a complex of the sulfuric acid ester of sucrose and aluminum hydroxide. Secondary polymerization with aluminum hydroxide forms intermolecular bridges between molecules of sulfate esters with aluminum. Limited dissociation of the complex occurs in gastric acid, but these anionic sulfate esters form insoluble adherent complexes with the proteinaceous exudate at the abraded surface of a crater of the ulcerated area in the stomach. This physical complex protects the ulcer from the erosive action of pepsin and bile salts. Sucralfate also stimulates synthesis and release of prostaglandins, bicarbonate, and epidermal and fibroblast growth factors. Significant ulcer healing effects are noted in placebo-controlled trials. Only small amounts of sucralfate are absorbed systemically. In renal impairment, there is a risk of accumulation of absorbed aluminum from the drug. Sucralfate reduces absorption of other drugs, including H2 antihistamines, quinolone antibiotics, phenytoin, and perhaps, warfarin

antineoplastic, antileukemia

Safety

• WGK Germany: 2
• RTECS: BD0900000
• HS Code: 29400090