Monensin sodium salt , ≥90%(HPLC) , 22373-78-0

Synonym(s):
Monensin A sodium salt;Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem

CAS NO.：22373-78-0

Empirical Formula: C36H63NaO12

Molecular Weight: 710.87

MDL number: MFCD00077826

EINECS: 244-941-7

PRODUCT Properties

• Melting point: 267-269 C
• alpha: 57.3 º (c=4.0, in MeOH)
• storage temp.: 2-8°C
• solubility: Soluble in methanol at 50mg/ml
• form: Off-white to beige solid
• color: White
• BRN: 4122200
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
• InChIKey: XOIQMTLWECTKJL-BEMBKCOJSA-M
• LogP: 3.716 (est)
• EPA Substance Registry System: Monensin, monosodium salt (22373-78-0)

Description and Uses

Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.

Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.

Safety

• Symbol(GHS): GHS06,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H300-H319-H334-H373-H411
• Precautionary statements: P260-P264-P273-P301+P310-P304+P340+P312-P305+P351+P338
• Hazard Codes: T,T+
• Risk Statements: 25-26/27/28
• Safety Statements: 36/37/39-45-22
• RIDADR: UN 3462 6.1/PG 2
• WGK Germany: 3
• RTECS: JH2830000
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 29419090