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A5454412

Monensin sodium salt , 97% , 22373-78-0

Synonym(s):
Monensin A sodium salt;Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem

CAS NO.:22373-78-0

Empirical Formula: C36H63NaO12

Molecular Weight: 710.87

MDL number: MFCD00077826

EINECS: 244-941-7

Pack Size Price Stock Quantity
250MG RMB239.20 In Stock
1G RMB692.00 In Stock
5G RMB2784.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 267-269 C
alpha  57.3 º (c=4.0, in MeOH)
storage temp.  2-8°C
solubility  Soluble in methanol at 50mg/ml
form  Off-white to beige solid
color  White
BRN  4122200
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey XOIQMTLWECTKJL-BEMBKCOJSA-M
LogP 3.716 (est)

Description and Uses

Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.

Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.

Safety

Symbol(GHS) 
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H300-H319-H334-H373-H411
Precautionary statements  P260-P264-P273-P301+P310-P304+P340+P312-P305+P351+P338
Hazard Codes  T,T+
Risk Statements  25-26/27/28
Safety Statements  36/37/39-45-22
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  JH2830000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29419090

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