Moxonidine , ≥98% , 75438-57-2

Synonym(s):
4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine

CAS NO.：75438-57-2

Empirical Formula: C9H12ClN5O

Molecular Weight: 241.68

MDL number: MFCD06795643

EINECS: 629-833-3

PRODUCT Properties

• Melting point: 217-219° (dec)
• Boiling point: 364.7±52.0 °C(Predicted)
• Density: 1.52±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
• form: Solid
• pka: 7.11±0.10(Predicted)
• color: White to Almost white
• Water Solubility: 800.3mg/L(temperature not stated)
• Merck: 14,6293
• InChIKey: WPNJAUFVNXKLIM-UHFFFAOYSA-N
• CAS DataBase Reference: 75438-57-2(CAS DataBase Reference)

Description and Uses

Moxonidine, which is structurally related to clonidine, is a new centrally acting antihypertensive that acts as a stronger agonist at imidazole receptors and a weaker agonist at α2-adrenergic receptors than clonidine. It is also reported to have less side effects and a much reduced potential to produce a rebound in blood pressure on withdrawal. Clinically, moxonidine appears to have comparable antihypertensive efficacy with the ACE inhibitors and calcium antagonists.

Antihypertensive;Imidazoline receptor agonist

Safety

• Symbol(GHS): GHS09,GHS06
• Signal word: Danger
• Hazard statements: H411-H301
• Precautionary statements: P264-P270-P301+P310-P321-P330-P405-P501
• RIDADR: UN 2811 6.1/PG III
• WGK Germany: 3
• RTECS: UV6260290
• HS Code: 2933.99.5300
• HazardClass: 6.1
• PackingGroup: III