Losartan Potassium (DuP 753) , ≥99% , 124750-99-8
Synonym(s):
2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt;2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt;Losartan potassium;Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide
CAS NO.：124750-99-8
Empirical Formula: C22H23ClKN6O
Molecular Weight: 462.01
MDL number: MFCD02092704
EINECS: 200-287-4
| Pack Size | Price | Stock | Quantity |
| 1G | RMB24.00 | In Stock |
|
| 5G | RMB28.80 | In Stock |
|
| 25G | RMB67.20 | In Stock |
|
| 100G | RMB236.80 | In Stock |
|
| 500g | RMB879.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 263-265°C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Freely soluble in water and in methanol, slightly soluble in acetonitrile. |
| form | powder or crystals |
| color | Off-white |
| Merck | 14,5583 |
| BRN | 5845770 |
| BCS Class | 1 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| InChI | InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1 |
| InChIKey | OXCMYAYHXIHQOA-UHFFFAOYSA-N |
| SMILES | C1(C=CC=CC=1C1=CC=C(CN2C(CO)=C(Cl)N=C2CCCC)C=C1)C1=NN=NN1[K] |
Description and Uses
Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor. Losartan is an AT1 receptor antagonist with a Ki value of 5-
antihypertensive, AT1 angiotensin II antagonist
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| RTECS | NI6755100 |
| HS Code | 2933290000 |
