PyridostigmineBromide , 10mMinDMSO , 101-26-8
Synonym(s):
3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide;Pyridostigmine bromide
CAS NO.：101-26-8
Empirical Formula: C9H13BrN2O2
Molecular Weight: 261.12
MDL number: MFCD00079283
EINECS: 202-929-9
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 154 °C |
| storage temp. | 2-8°C |
| solubility | Very soluble in water and in ethanol (96 per cent). |
| form | Solid |
| color | White to Almost white |
| Merck | 14,7977 |
| BCS Class | 3 |
| InChIKey | VNYBTNPBYXSMOO-UHFFFAOYSA-M |
| CAS DataBase Reference | 101-26-8(CAS DataBase Reference) |
| EPA Substance Registry System | Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1) (101-26-8) |
Description and Uses
Pyridostigmine is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.35 and 1 μM, respectively, for the human enzymes). Pyridostigmine (10 μM) reduces decreases in AChE activity induced by the organophosphate pesticides diisopropyl fluorophosphate, chlorpyrifos-oxon, diazinon-oxon, paraoxon, and malaoxon in isolated bovine red blood cells. It also reduces soman-induced membrane depolarization and decreases in AChE activity in isolated human muscle bundles in a concentration-dependent manner. Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia and increases in sympathetic tone in mice following myocardial infarction induced by left coronary artery ligation. Formulations containing pyridostigmine have been used in the treatment of myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.
Cholinergic, used in the treatment of myasthenia gravis, and is a pre-exposure antidote to chemical warfare agents.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300+H310+H330-H317 |
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28-43 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | UU5270000 |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 2933399090 |
| Hazardous Substances Data | 101-26-8(Hazardous Substances Data) |
| Toxicity | man,TDLo,oral,9mg/kg (9mg/kg),PERIPHERAL NERVE AND SENSATION: FASCICULATIONS,Israel Journal of Medical Sciences. Vol. 27, Pg. 659, 1991. |
