Memantine Hydrochloride , 98% , 41100-52-1

Synonym(s):
3,5-Dimethyl-1-adamantanamine hydrochloride;3,5-Dimethylamantadine hydrochloride;3,5-Dimethyltricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride;Memantine hydrochloride

CAS NO.：41100-52-1

Empirical Formula: C12H22ClN

Molecular Weight: 215.76

MDL number: MFCD00214336

EINECS: 255-219-6

PRODUCT Properties

• Melting point: 292 °C
• storage temp.: Inert atmosphere,2-8°C
• solubility: Soluble in Water (up to 20 mg/ml)
• form: Fine Powder
• color: White
• Water Solubility: Soluble in water (100mM)
• Merck: 14,5806
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
• InChI: InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
• InChIKey: LDDHMLJTFXJGPI-UHFFFAOYSA-N
• SMILES: C12(N)CC3(C)CC(CC(C)(C3)C1)C2.[H]Cl
• CAS DataBase Reference: 41100-52-1(CAS DataBase Reference)

Description and Uses

Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM. It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau_194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I₁^PP2A in vitro. In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory in the AAV1-I₁^PP2A rat model of Alzheimer''s disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats. It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.

Anti Alzheimer's

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 29213000