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A4345112

Fasudil Hydrochloride , 98% , 105628-07-7

Synonym(s):
1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride;Fasudil dihydrochloride

CAS NO.:105628-07-7

Empirical Formula: C14H18ClN3O2S

Molecular Weight: 327.83

MDL number: MFCD00943198

EINECS: 805-833-0

Pack Size Price Stock Quantity
100MG RMB56.80 In Stock
250mg RMB77.60 In Stock
500MG RMB143.20 In Stock
1g RMB217.60 In Stock
5g RMB812.00 In Stock
25g RMB2420.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 220.5°; mp 219.3° (Shirotani)
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  H2O: >200 mg/mL
form  solid
color  white
Water Solubility  Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.
Merck  14,3942
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChI InChI=1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
InChIKey LFVPBERIVUNMGV-UHFFFAOYSA-N
SMILES N1(S(C2=CC=CC3=C2C=CN=C3)(=O)=O)CCCNCC1.[H]Cl.[H]Cl
CAS DataBase Reference 105628-07-7(CAS DataBase Reference)

Description and Uses

Fasudil hydrochloride, a novel calcium antagonistic vasodilator, was marketed for the treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). Fasudil is also a potent inhibitor of myosin light chain kinase and protein kinase C. In contrast to other calcium channel blockers, which regulate the influx of calcium ions through the cell membrane but not involved in the intracellular regulatory mechanism of the calcium, fasudil was suggested to have an intracellular mode of action in relaxing vascular smooth muscle. In patients with neurological deficits due to vasospasm, fasudil decreased the occurrence of angiographic severe and symptomatic vasospasm and cerebral infarction without decreasing systemic blood pressure. Fasudil is reportedly in clinical trials for acute ischemic stroke, sequelae of cerebral vascular diseases and angina pectoris.

Fasudil monohydrochloride is used in the prevention and treating cardiovascular and cerebrovascular diseases. It is also used in the inhibition of proliferation of vascular smooth muscle cells. It serves as a selective Rho-associated protein kinase (ROCK) inhibitor. Further, it protects against methyl mercury-induced axonal degeneration.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a
Risk Statements  22
Safety Statements  36-60
WGK Germany  3
RTECS  HM4031166
HS Code  29339900
Toxicity LD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga)

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