Isatoic Anhydride , >98.0%(HPLC)(T) , 118-48-9

Synonym(s):
3,1-Benzoxazine-2,4(1H)-dione;Anthranilic acid N-carboxylic acid anhydride;Anthranilic acid N-carboxylic acid anhydride, 1,4-Dihydro-2H-3,1-benzoxazin-2,4-dione, 2H-3,1-Benzoxazine-2,4-(1H)-dione;Isatoic anhydride

CAS NO.：118-48-9

Empirical Formula: C8H5NO3

Molecular Weight: 163.13

MDL number: MFCD00006700

EINECS: 204-255-0

PRODUCT Properties

• Melting point: 233 °C (dec.) (lit.)
• Boiling point: 290.19°C (rough estimate)
• Density: 1,52 g/cm³
• vapor density: 5.6 (vs air)
• refractive index: 1.5510 (estimate)
• Flash point: 308 °C
• storage temp.: Store below +30°C.
• solubility: 0.3g/l
• pka: 11.06±0.20(Predicted)
• form: Powder
• color: Beige to brown
• Water Solubility: decomposes
• Sensitive: Moisture Sensitive
• BRN: 136786
• LogP: 0.978 (est)
• CAS DataBase Reference: 118-48-9(CAS DataBase Reference)
• NIST Chemistry Reference: Isatoic anhydride(118-48-9)
• EPA Substance Registry System: 2H-3,1-Benzoxazine-2,4(1H)-dione (118-48-9)

Description and Uses

Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317-H319
• Precautionary statements: P261-P264-P272-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36-43
• Safety Statements: 24-26-37
• WGK Germany: 1
• RTECS: DM3100000
• F: 3
• Autoignition Temperature: >600 °C
• TSCA: Yes
• HS Code: 29349990
• Hazardous Substances Data: 118-48-9(Hazardous Substances Data)
• Toxicity: LD50 orally in Rabbit: > 6400 mg/kg LD50 dermal Rabbit > 2000 mg/kg