Home Categories API Idarubicin HCl
A5040612

Idarubicin HCl , ≥98% , 57852-57-0

Synonym(s):
(7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione;4-Demethoxydaunorubicin hydrochloride;DMDR;Idamycin;IMI-30

CAS NO.:57852-57-0

Empirical Formula: C26H28ClNO9

Molecular Weight: 533.95

MDL number: MFCD00897212

EINECS: 260-990-7

Pack Size Price Stock Quantity
1MG RMB111.20 In Stock
5MG RMB399.20 In Stock
10MG RMB695.20 In Stock
50MG RMB1919.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 183-185 C
alpha  D20 +205° (c = 0.1 in methanol) (Arcamone); D20 +188° (c = 0.10 in methanol) (Kimura)
storage temp.  Inert atmosphere,2-8°C
solubility  ≥26.7 mg/mL in DMSO; insoluble in EtOH; ≥2.39 mg/mL in H2O with ultrasonic
form  solid
color  Orange to red
Stability: Hygroscopic, Light Sensitive
InChIKey JVHPTYWUBOQMBP-RVFAQHLVSA-N
SMILES C12=C(O)C3=C(C(=O)C4C=CC=CC=4C3=O)C(O)=C1C[C@@](O)(C(=O)C)C[C@]2([H])O[C@@H]1O[C@H]([C@@H](O)[C@@H](N)C1)C.Cl |&1:19,25,28,30,31,33,r|

Description and Uses

Idarubicin hydrochloride is a derivative of daunorubicin indicated for acute nonlymphocytic leukemia, acute lymphocytic leukemia, and acute myeloid leukemia. Compared with daunorubicin, idarubicin hydrochloride is less cardiotoxic, has milder side effects, is orally active and more potent in experimental leukemias. Idarubicin hydrochloride is also reportedly active in daunorubicin-resistant patients, breast cancer,Hodgkin's and non-Hodgkin's lymphoma.

Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL

Safety

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H300-H351-H360
Precautionary statements  P201-P280-P301+P330+P331+P310-P308+P313
Hazard Codes  T+,Xn
Risk Statements  60-61-28-40
Safety Statements  53-45-36-22
RIDADR  UN 2811
WGK Germany  3
RTECS  HB7877000
HS Code  2941906000

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