HEPPS , ≥99.5%(T) , 16052-06-5

Synonym(s):
N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid);4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid;4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid;HEPPS

CAS NO.：16052-06-5

Empirical Formula: C9H20N2O4S

Molecular Weight: 252.33

MDL number: MFCD00006160

EINECS: 240-198-8

PRODUCT Properties

• Melting point: 237-239 °C(lit.)
• Density: 1.2684 (rough estimate)
• refractive index: 1.6800 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• solubility: H₂O: 1 M at 20 °C, clear, colorless
• form: Powder/Solid
• color: White
• PH: 5.0-6.5 (25℃, 0.1M in H2O)
• pka: 8.0(at 25℃)
• PH Range: 7.3 - 8.7
• Water Solubility: Soluble in water. 25.2 g/L (20°C)
• λmax: λ: 260 nm Amax: 0.055; λ: 280 nm Amax: 0.045
• BRN: 3957385
• CAS DataBase Reference: 16052-06-5(CAS DataBase Reference)
• EPA Substance Registry System: 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)- (16052-06-5)

Description and Uses

HEPPS (EPPS) is a commonly used Good's buffer. It is often used as separator in ultrathin isoelectric focusing gels and enhances the resolution of phosphoglucomutase. It is used as a buffering agent in biology and biochemistry. HEPPS is a biological buffer with a useful pH range of 7.3-8.7 and a pKa=8.0 at 25°C. Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice. HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H332-H335
• Precautionary statements: P280-P305+P351+P338-P310
• Hazard Codes: Xi
• Risk Statements: 36/37/38-22
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• RTECS: TM2649130
• TSCA: Yes
• HazardClass: IRRITANT
• HS Code: 29335995
• Toxicity: quail,LD50,oral,> 316mg/kg (316mg/kg),Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.