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A4722312

HEPPS , ≥99.0%(T) , 16052-06-5

Synonym(s):
N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid);4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid;4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid;HEPPS

CAS NO.:16052-06-5

Empirical Formula: C9H20N2O4S

Molecular Weight: 252.33

MDL number: MFCD00006160

EINECS: 240-198-8

Pack Size Price Stock Quantity
5G RMB28.00 In Stock
25G RMB71.20 In Stock
100G RMB205.60 In Stock
500G RMB702.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 237-239 °C(lit.)
Density  1.2684 (rough estimate)
refractive index  1.6800 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  H2O: 1 M at 20 °C, clear, colorless
form  Powder/Solid
color  White
PH 5.0-6.5 (25℃, 0.1M in H2O)
pka 8.0(at 25℃)
PH Range 7.3 - 8.7
Water Solubility  Soluble in water. 25.2 g/L (20°C)
λmax λ: 260 nm Amax: 0.055
λ: 280 nm Amax: 0.045
BRN  3957385
CAS DataBase Reference 16052-06-5(CAS DataBase Reference)
EPA Substance Registry System 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)- (16052-06-5)

Description and Uses

HEPPS (EPPS) is a commonly used Good's buffer. It is often used as separator in ultrathin isoelectric focusing gels and enhances the resolution of phosphoglucomutase. It is used as a buffering agent in biology and biochemistry. HEPPS is a biological buffer with a useful pH range of 7.3-8.7 and a pKa=8.0 at 25°C. Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice. HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
Hazard Codes  Xi
Risk Statements  36/37/38-22
Safety Statements  24/25-36-26
WGK Germany  3
RTECS  TM2649130
TSCA  Yes
HazardClass  IRRITANT
HS Code  29335995
Toxicity quail,LD50,oral,> 316mg/kg (316mg/kg),Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.

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