Home Categories Pharmaceutical intermediates 4-Hydroxypyridine
A4703812

4-Hydroxypyridine , 97% , 626-64-2

Synonym(s):
4-Pyridinol;4-Pyridone

CAS NO.:626-64-2

Empirical Formula: C5H5NO

Molecular Weight: 95.1

MDL number: MFCD00006419

EINECS: 210-958-3

Pack Size Price Stock Quantity
5g RMB23.20 In Stock
25G RMB72.80 In Stock
100G RMB224.80 In Stock
500G RMB888.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 150-151 °C (lit.)
Boiling point: 230-235 °C/12 mmHg (lit.)
Density  1.1418 (rough estimate)
refractive index  1.5939 (estimate)
Flash point: 221 °C
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  DMSO (Slightly), Methanol (Slightly)
form  Powder or Chunks
pka 3.2(at 20℃)
color  Beige to light brown
Water Solubility  Soluble
BRN  105800
InChIKey GCNTZFIIOFTKIY-UHFFFAOYSA-N
LogP -1.300 (est)
CAS DataBase Reference 626-64-2(CAS DataBase Reference)
NIST Chemistry Reference 4-Pyridinol(626-64-2)
EPA Substance Registry System 4-Pyridinol (626-64-2)

Description and Uses

4-Hydroxypyridine, available from pyridylpyridinium chloride hydrochloride, is the substrate for diodone and its n-propyl ester, propyliodone. 4-Hydroxypyridine (4-HP) is a non-nucleophilic analog of the product phenol found to bind specifically to and stabilize the aminoacrylate intermediate. When 4-HP is added to Tyrosine phenol-lyase (TPL) reactions, an absorption peak at 340 nm is observed. The formation of the 340 nm peak correlates with the decay of the quinonoid intermediate peak at 505 nm, with a clean isosbestic point, and the observed rate constants show an inverse dependence on the concentration of 4-HP. These results confirm that the observed peak at 340 nm is due to the formation of the amino acrylate intermediate[1-2].

4-Hydroxypyridine was used in the synthesis of (Ag3MoO3F3) (Ag3MoO4)Cl by hydro(solvato)thermal methods. It was used as model compound to study the natural photodegradation of representative aquatic environmental contaminants.

Safety

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-41-37/38-22
Safety Statements  26-36-37/39-39
WGK Germany  3
RTECS  UU7701450
3-8-10
Hazard Note  Harmful/Irritant
TSCA  Yes
HazardClass  IRRITANT
HS Code  29339900

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