Gemfibrozil , ≥99% , 25812-30-0

Synonym(s):
2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid;2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid;5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid

CAS NO.：25812-30-0

Empirical Formula: C15H22O3

Molecular Weight: 250.33

MDL number: MFCD00079335

EINECS: 247-280-2

PRODUCT Properties

• Melting point: 61-63°C
• Boiling point: 158-159 C
• Density: 1.1109 (rough estimate)
• refractive index: 1.5020 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, very soluble in methylene chloride, freely soluble in anhydrous ethanol and in methanol.
• form: powder
• pka: 4.75±0.45(Predicted)
• color: White to Off-White
• Water Solubility: >0.5g/L(temperature not stated)
• Merck: 14,4388
• BCS Class: 2

Description and Uses

Gemfibrozil is a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist (EC₅₀s = 193.3 and 147.8 μM, respectively, in transactivation assays). In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE^-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.

This drug is used for hyperlipoproteinemia that cannot be corrected by a special diet or by physical exertion.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn,Xi
• Risk Statements: 22-63-62-46-36/38-21
• Safety Statements: 36-53-36/37-26-25
• WGK Germany: 3
• RTECS: YV7120000
• HazardClass: IRRITANT
• HS Code: 2918992090
• Toxicity: LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz)