Simvastatin , ≥97%(HPLC) , 79902-63-9

Synonym(s):
MK-733;MK-733, L-Type Calcium Channel Blocker VI;Simvastatin;Simvastatin - CAS 79902-63-9 - Calbiochem;SVA

CAS NO.：79902-63-9

Empirical Formula: C25H38O5

Molecular Weight: 418.57

MDL number: MFCD00072007

EINECS: 616-751-8

PRODUCT Properties

• Melting point: 127-132 °C (lit.)
• alpha: D25 +292° (c = 0.5% in acetonitrile)
• Boiling point: 564.9±50.0 °C(Predicted)
• Density: 1.11±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: ≥20mg/mL
• pka: 13.49±0.40(Predicted)
• form: solid
• color: white
• optical activity: [α]/D +275±25°, c = 1 in acetonitrile
• Merck: 14,8539
• BCS Class: 2
• Stability: Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
• CAS DataBase Reference: 79902-63-9(CAS DataBase Reference)
• NIST Chemistry Reference: Simvastatin(79902-63-9)
• EPA Substance Registry System: Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester (79902-63-9)

Description and Uses

Simvastatin is an once-daily hypolipemic, an analog of lovastatin indicated for the treatment of atherosclerosis. In patients with Type IN or IIB hypercholesterolemia, simvastatin reportedly produces significant reductions in total serum cholesterol, LDL, mglycerides and apolipoprotein-B, while HDL and apolipoprotein-A levels are increased.

A HMGCR inhibitor and anti-proliferative agent.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361d
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 2
• RTECS: EK7798000
• HS Code: 29322090
• Hazardous Substances Data: 79902-63-9(Hazardous Substances Data)