A4649912
Ouabain , ≥98% , 630-60-4
Synonym(s):
1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L -mannopyranoside);Acocantherine;G-Strophanthin;Ouabain octahydrate
CAS NO.：630-60-4
Empirical Formula: C29H44O12
Molecular Weight: 584.66
MDL number: MFCD00003688
EINECS: 211-139-3
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 200°C |
| Boiling point: | 561.69°C (rough estimate) |
| Density | 1.1941 (rough estimate) |
| refractive index | -32 ° (C=1, H2O) |
| storage temp. | Desiccate at -20°C |
| solubility | H2O: 10 mg/mL cold |
| pka | 13.04±0.70(Predicted) |
| form | powder |
| color | white |
| Water Solubility | 13g/L(25 ºC) |
| Merck | 6901 |
| Stability: | Hygroscopic |
Description and Uses
One of several cardiac glycosides that have been used clinically as cardiotonic agents and diuretics. Ouabain is obtained from the seeds of Strophanthus gratus, Acokanthera ouabaio, and related species. It was formerly prescribed under the name strophanthuis as the purified seed extract.
Ouabain is a Na+/K+-ATPase inhibitor hormone, which negatively modulates allergic airway inflammation induced by ovalbumin (OVA).
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301-H331-H373 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P260-P314-P501 |
| Hazard Codes | T |
| Risk Statements | 23/25-33 |
| Safety Statements | 45 |
| RIDADR | UN 1544 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | RN3850000 |
| F | 8 |
| Toxicity | LD50 oral in guinea pig: 8280ug/kg |
