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A4649812

GF109203X , ≥99% , 133052-90-1

Synonym(s):
Bisindolylmaleimide I;Bisindolylmaleimide I hydrochloride;InSolution ;3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide;3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride

CAS NO.:133052-90-1

Empirical Formula: C25H24N4O2

Molecular Weight: 412.48

MDL number: MFCD00236428

Pack Size Price Stock Quantity
1MG RMB239.20 In Stock
5mg RMB792.00 In Stock
10MG RMB959.20 In Stock
50MG RMB3599.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 280℃ (decomposition)
Boiling point: 685.6±55.0 °C(Predicted)
Density  1.30±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: ~1 mg/mlsoluble
form  Liquid
pka 8.13±0.60(Predicted)
color  Orange
Water Solubility  Insoluble in water.
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.

Description and Uses

GF-109203X (133052-90-1) is a potent and selective protein kinase C inhibitor (IC50 = 10 nM; cAMP-dependent protein kinase IC50 = 2 μM and phosphorylase kinase IC50 = 0.7 μM). Inactive against the tyrosine kinases EGFR, PGDFR and Insulin receptor. Potent inhibitor of GSK-3β in cell lysates (IC50 = 360nM) and GSK-3β immunoprecipitates (IC50 = 170nM) derived from rat epididymal adipocytes.2 Cell permeable.

Bisindolylmaleimide is used as a highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3, used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals, very potent and selective inhibitor of protein kinase C.

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H350
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
Hazard Codes  Xn
Risk Statements  40-22
Safety Statements  36/37
WGK Germany  3
RTECS  UX9590000
HS Code  2925199590

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