3,4-Di(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione , 98% , 113963-68-1

Synonym(s):
2,3- bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045;2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045;Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem

CAS NO.：113963-68-1

Empirical Formula: C21H15N3O2

Molecular Weight: 341.36

MDL number: MFCD00236433

EINECS: 604-604-1

PRODUCT Properties

• Melting point: >260 °C
• Boiling point: 655.7±55.0 °C(Predicted)
• Density: 1.450±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: DMSO: soluble
• form: solid
• pka: 15.89±0.30(Predicted)
• color: Orange
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Description and Uses

Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• WGK Germany: 3