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A4511956

Nicaraven , 98% , 79455-30-4

CAS NO.:79455-30-4

Empirical Formula: C15H16N4O2

Molecular Weight: 284.31

MDL number: MFCD00411904

EINECS: 1806241-263-5

Pack Size Price Stock Quantity
10mg RMB230.40 In Stock
50mg RMB446.40 In Stock
250mg RMB1866.40 In Stock
1g RMB4799.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 156-157°
Boiling point: 635.9±40.0 °C(Predicted)
Density  1.213±0.06 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 2 mg/ml
form  A crystalline solid
pka 12.93±0.46(Predicted)
color  White to off-white

Description and Uses

Nicaraven is an antioxidant that exhibits hydroxyl radical scavenging activity in vitro. Nicaraven (1-3 mg/kg per min, i.v.) reduces occurrence of chronic cerebral vasospasms in a dose-dependent manner in a canine model of subarachnoid hemorrhage. In a canine model of warm hepatic ischemia and reperfusion injury, nicaraven (2 mg/kg per min, i.v.) reduces liver enzyme release and inhibits lipid peroxidation and neutrophil infiltration in the liver. Nicaraven (100 mg/kg per day, i.p.) also decreases plasma levels of the inflammatory cytokines Il-6 and Tnf-α and the urinary levels of 8-oxo-2''-deoxyguanosine, a marker of DNA oxidation, in a mouse model of radiation-induced injury.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501

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