A7368112
SB705498 , 98% , 501951-42-4
CAS NO.：501951-42-4
Empirical Formula: C17H16BrF3N4O
Molecular Weight: 429.23
MDL number: MFCD13152399
| Pack Size | Price | Stock | Quantity |
| 1MG | RMB159.20 | In Stock |
|
| 5MG | RMB575.20 | In Stock |
|
| 10MG | RMB1079.20 | In Stock |
|
| 25mg | RMB2399.20 | In Stock |
|
| 50MG | RMB4319.20 | In Stock |
|
| 100mg | RMB7775.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 506.9±50.0 °C(Predicted) |
| Density | 1.59 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (>25 mg/ml) |
| pka | 13.00±0.20(Predicted) |
| form | solid |
| color | White |
| Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin . SB-705498 is an orally bioavailable, competitive antagonist of the capsaicin-mediated activation of TRPV1 receptors (pKis = 7.6, 7.5, and 7.3 for human, rat, and guinea pig, respectively). It has been shown to induce rapid, reversible inhibition of capsaicin (IC50 = 3 nM)-, acid (pH 5.3)-, or heat (50°C; IC50 = 6 nM)-mediated activation of human TRPV1 (at -70 mV).
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
