A7809212
Tideglusib , ≥98% , 865854-05-3
Synonym(s):
4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione;NP031112;NP-12
CAS NO.：865854-05-3
Empirical Formula: C19H14N2O2S
Molecular Weight: 334.39
MDL number: MFCD18633296
EINECS: 640-411-8
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB239.20 | In Stock |
|
| 25MG | RMB799.20 | In Stock |
|
| 100MG | RMB1735.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 148 - 150oC |
| Boiling point: | 511.3±43.0 °C(Predicted) |
| Density | 1.393 |
| storage temp. | 2-8°C |
| solubility | DMSO: >15mg/mL |
| form | powder |
| pka | -1.51±0.20(Predicted) |
| color | white to beige |
| InChI | InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2 |
| InChIKey | PMJIHLSCWIDGMD-UHFFFAOYSA-N |
| SMILES | S1C(=O)N(CC2=CC=CC=C2)C(=O)N1C1=C2C(C=CC=C2)=CC=C1 |
Description and Uses
Tideglusib has been used:
- as a reference compound in ADP-GloTM Kinase assay
- as an allosteric inhibitor of GSK-3β to study its effects on myocardial remodeling and angiogenesis
- as a differentiation agent (specifically a glycogen synthase kinase (GSK)-3β inhibitor) to convert fibroblast cells into octamer-binding transcription factor-4 (OCT4)+ and vascular endothelial growth factor receptor-2 (VEGFR-2/fetal liver kinase-1 (FLK1)+ cells
Safety
| WGK Germany | 3 |
