Home Categories Biochemical Engineering Fmoc-Lys(Boc)-OH
A4300312

Fmoc-Lys(Boc)-OH , 98% , 71989-26-9

Synonym(s):
Nα-Fmoc-Nε-Boc-L-lysine;Fmoc-Lys(Boc)-OH;N-α-Fmoc-N-ε-t.-Boc-L-lysine

CAS NO.:71989-26-9

Empirical Formula: C26H32N2O6

Molecular Weight: 468.54

MDL number: MFCD00037138

EINECS: 276-256-4

Pack Size Price Stock Quantity
1g RMB23.20 In Stock
5G RMB36.80 In Stock
25G RMB120.00 In Stock
100G RMB346.40 In Stock
500g RMB1589.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 130-135 °C (dec.)
alpha  -12 º (c=2,DMF 24 ºC)
Boiling point: 570.69°C (rough estimate)
Density  1.2301 (rough estimate)
refractive index  -12 ° (C=1, DMF)
storage temp.  Store below +30°C.
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka 3.88±0.21(Predicted)
form  Powder
color  White
optical activity [α]20/D 12±1°, c = 1% in DMF
Water Solubility  Slightly soluble in water.
BRN  4217767
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey UMRUUWFGLGNQLI-QFIPXVFZSA-N
CAS DataBase Reference 71989-26-9(CAS DataBase Reference)

Description and Uses

Fmoc-Lys(Boc)-OH (Na-Fmoc-Ne-Boc-L-lysine) has emerged as the standard Fmoc-Lys derivative used in peptide synthesis. The Boc group on the side chain is stable under basic conditions and remains in place even through many Fmoc deprotection cycles. The Boc group of Fmoc-Lys(Boc)-OH is readily removed with trifluoroacetic acid (TFA) during cleavage of the peptide product from Wang resin or Rink amide resin. It could self-assemble to sphere like morphology in all conditions irrespective of concentration and heating. To prepare the FAPI-04 dimer complex, this compound could used as a linker to conjugate two FAPI-04 structures by an amide reaction. After further modification, the product can perform cancer theranostics[1-2].

Fmoc-Lys(Boc)-OH can be used for:

  • The solid-phase synthesis of pentasubstituted dihydroimidazolylbutyl dihydroimidazol-3-ium salts by coupling with p-methylbenzhydrylamine (MBHA) resin.
  • Fmoc-based peptide synthesis of bis-naphthalene diimide, a threading intercalator.
  • Synthesis of ε-Boc-ε-(3,5-bis-trifluoromethyl-benzyl)-α-Fmoc-L-Lysine to be used as 19F NMR based screening tool.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
Hazard Codes  Xi
Safety Statements  24/25-36/37/39-27-26
WGK Germany  3
HS Code  29224999

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