Fmoc-Lys(Boc)-OH , 98% , 71989-26-9

Synonym(s):
N_α-Fmoc-N_ε-Boc-L-lysine;Fmoc-Lys(Boc)-OH;N-α-Fmoc-N-ε-t.-Boc-L-lysine

CAS NO.：71989-26-9

Empirical Formula: C26H32N2O6

Molecular Weight: 468.54

MDL number: MFCD00037138

EINECS: 276-256-4

PRODUCT Properties

• Melting point: 130-135 °C (dec.)
• alpha: -12 º (c=2,DMF 24 ºC)
• Boiling point: 570.69°C (rough estimate)
• Density: 1.2301 (rough estimate)
• refractive index: -12 ° (C=1, DMF)
• storage temp.: Store below +30°C.
• solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
• pka: 3.88±0.21(Predicted)
• form: Powder
• color: White
• optical activity: [α]20/D 12±1°, c = 1% in DMF
• Water Solubility: Slightly soluble in water.
• BRN: 4217767
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: UMRUUWFGLGNQLI-QFIPXVFZSA-N

Description and Uses

Fmoc-Lys(Boc)-OH (Na-Fmoc-Ne-Boc-L-lysine) has emerged as the standard Fmoc-Lys derivative used in peptide synthesis. The Boc group on the side chain is stable under basic conditions and remains in place even through many Fmoc deprotection cycles. The Boc group of Fmoc-Lys(Boc)-OH is readily removed with trifluoroacetic acid (TFA) during cleavage of the peptide product from Wang resin or Rink amide resin. It could self-assemble to sphere like morphology in all conditions irrespective of concentration and heating. To prepare the FAPI-04 dimer complex, this compound could used as a linker to conjugate two FAPI-04 structures by an amide reaction. After further modification, the product can perform cancer theranostics[1-2].

Fmoc-Lys(Boc)-OH can be used for:

• The solid-phase synthesis of pentasubstituted dihydroimidazolylbutyl dihydroimidazol-3-ium salts by coupling with p-methylbenzhydrylamine (MBHA) resin.
• Fmoc-based peptide synthesis of bis-naphthalene diimide, a threading intercalator.
• Synthesis of ε-Boc-ε-(3,5-bis-trifluoromethyl-benzyl)-α-Fmoc-L-Lysine to be used as ¹⁹F NMR based screening tool.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
• Hazard Codes: Xi
• Safety Statements: 24/25-36/37/39-27-26
• WGK Germany: 3
• HS Code: 29224999