Fmoc-Cys(Trt)-OH , 98% , 103213-32-7

Synonym(s):
N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine;N_α-Fmoc-S-trityl-L-cysteine;Fmoc-Cys(Trt)-OH;N-α-Fmoc-S-trityl-L-cysteine

CAS NO.：103213-32-7

Empirical Formula: C37H31NO4S

Molecular Weight: 585.71

MDL number: MFCD00038538

EINECS: 600-408-4

PRODUCT Properties

• Melting point: 170-173 °C(lit.)
• alpha: 16 º (c=1, THF)
• Boiling point: 763.4±60.0 °C(Predicted)
• Density: 1.270±0.06 g/cm3(Predicted)
• refractive index: 18 ° (C=1, THF)
• storage temp.: 2-8°C
• solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
• pka: 3.70±0.10(Predicted)
• form: Powder
• color: White to almost white
• optical activity: [α]20/D +16.0±2°, c = 1% in THF
• Water Solubility: Insoluble in water. Soluble in most organic solvents.
• BRN: 4221286
• InChIKey: KLBPUVPNPAJWHZ-UMSFTDKQSA-N

Description and Uses

Fmoc-Cys(Trt)-OH is an N-terminal protected cysteine derivative used in peptide synthesis. Some of the examples are:

• Synthesis of mono- and bi-functionalized platinum(IV) complexes to target angiogenic tumor vasculature.
• Synthesis of proteins through native chemical ligation of peptide hydrazides as thioester surrogates via solid-phase synthesis.
• Synthesis of glycoconjugates by conjugating reducing sugars to cysteine residues of peptides.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-26
• WGK Germany: 3
• F: 9-21
• Hazard Note: Irritant
• HS Code: 29309090