Eplerenone , ≥98% , 107724-20-9

Synonym(s):
Eplerenone;Inspra;Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-;Eplerenone [USAN];Epoxymexrenone

CAS NO.：107724-20-9

Empirical Formula: C24H30O6

Molecular Weight: 414.49

MDL number: MFCD07783647

EINECS: 600-850-8

PRODUCT Properties

• Melting point: 241-243°C
• alpha: D +5° (c = 0.437 in chloroform)
• Boiling point: 597.9±50.0 °C(Predicted)
• Density: 1.31±0.1 g/cm3(Predicted)
• storage temp.: Store at RT
• solubility: DMSO: soluble2mg/mL, clear (warmed)
• form: powder
• color: white to beige
• λmax: 240nm(lit.)
• Merck: 14,3625
• InChIKey: UZZAHAKTLYRDOK-MGIDJNSKSA-N
• SMILES: [C@@]123[C@@]4(C)CCC(=O)C=C4C[C@@H](C(OC)=O)[C@@]1([H])[C@]1([H])CC[C@]4(CCC(=O)O4)[C@]1(C[C@@]2([H])O3)C |&1:0,1,10,15,17,21,27,29,r|

Description and Uses

Eplerenone is a mineralocorticoid receptor antagonist. It is selective for the mineralocorticoid receptor over glucocorticoid, androgen, progesterone, and estrogen receptors in radioligand binding assays (IC₅₀s = 138, 6,920, 523, >10,000, and 5,702 nM, respectively). Eplerenone inhibits aldosterone-induced mineralocorticoid activity in a luciferase assay (IC₅₀ = 122 nM). In vivo, eplerenone (100 mg/kg per day) reduces urinary albumin secretion and glomerulosclerosis in the Dahl salt-sensitive rat model of hypertension and nephropathy. It reduces myocardial IL-1β levels and collagen deposition, as well as improves left ventricular systolic dysfunction in a mouse model of acute myocardial infarction. Formulations containing eplerenone have been used in the treatment of hypertension and heart failure after myocardial infarction.

Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM. It is used as an adjunct in the management of chronic heart failure. It is similar to the diuretic spironolactone, though it may be more specific for the mineralocorticoid receptor and is sp

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• RIDADR: 3077
• WGK Germany: 3
• HS Code: 29322090