A4013412
Epothilone A , ≥98% , 152044-53-6
Synonym(s):
EpoA
| Pack Size | Price | Stock | Quantity |
| 1MG | RMB479.20 | In Stock |
|
| 5MG | RMB892.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 95℃ |
| alpha | D21 -47.1° (c = 1.0 in methanol) |
| Boiling point: | 683.3±55.0 °C(Predicted) |
| Density | 1.143 |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| pka | 13.57±0.70(Predicted) |
| form | solid |
| color | White to Off-White |
| Stability: | Stable under recommended storage conditions., Stable Under Recommended Storage C |
Description and Uses
The epothilones are a novel class of antineoplastic agents possessing antitubulin activity. Epothilone A, B isolated from Sorangium cellulosum was associated with cell cycle arrest at G2/M transition and apoptosis that was resisted with overexpression of β-tubulin and P-glycoprotein in human bladder carcinoma cell.
Safety
| WGK Germany | 3 |
![(1S,3S,7S,10R,11S,12S,16R)-3-[(1E)-2-[2-(Aminomethyl)-4-thiazolyl]-1-methylethenyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione](https://img.chemicalbook.com/CAS/GIF/280578-49-6.gif)