Epothilone B , ≥98%(HPLC) , 152044-54-7

Synonym(s):
EPO906;EpoB;Patupilone

CAS NO.：152044-54-7

Empirical Formula: C27H41NO6S

Molecular Weight: 507.68

MDL number: MFCD02101921

EINECS: 604-822-6

PRODUCT Properties

• Melting point: 95-97°C
• alpha: D21 -35° (c = 0.7 in methanol)
• Boiling point: 680.2±55.0 °C(Predicted)
• Density: 1.136
• storage temp.: Store at -20°C
• solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 35 mg/ml).
• pka: 13.57±0.70(Predicted)
• form: White to off-white solid
• color: colorless
• optical activity: -35.021 (methanol)
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
• InChIKey: QXRSDHAAWVKZLJ-PVYNADRNSA-N

Description and Uses

Epothilone B (152044-54-7) induces microtubule polymerization. Causes cell cycle arrest at the G2-M transition (EC50 = 32 nM for HeLa cells). Induces apoptosis. Cell permeable.

Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively). Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.

Safety

• Symbol(GHS): GHS08,GHS09,GHS06
• Signal word: Danger
• Hazard statements: H310-H341-H360-H372-H315-H317-H410-H300
• Precautionary statements: P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P260-P264-P270-P314-P501-P273-P391-P501-P201-P202-P281-P308+P313-P405-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P310-P321-P330-P405-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
• WGK Germany: 3
• HS Code: 29419090