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A3932212

Epothilone B , ≥98%(HPLC) , 152044-54-7

Synonym(s):
EPO906;EpoB;Patupilone

CAS NO.:152044-54-7

Empirical Formula: C27H41NO6S

Molecular Weight: 507.68

MDL number: MFCD02101921

EINECS: 604-822-6

Pack Size Price Stock Quantity
1MG RMB159.20 In Stock
5MG RMB559.20 In Stock
25mg RMB3192.00 In Stock
100mg RMB5599.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 95-97°C
alpha  D21 -35° (c = 0.7 in methanol)
Boiling point: 680.2±55.0 °C(Predicted)
Density  1.136
storage temp.  Store at -20°C
solubility  Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 35 mg/ml).
form  White to off-white solid
pka 13.57±0.70(Predicted)
color  colorless
optical activity -35.021 (methanol)
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey QXRSDHAAWVKZLJ-PVYNADRNSA-N
CAS DataBase Reference 152044-54-7

Description and Uses

Epothilone B (152044-54-7) induces microtubule polymerization. Causes cell cycle arrest at the G2-M transition (EC50 = 32 nM for HeLa cells). Induces apoptosis. Cell permeable.

Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively). Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.

Safety

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