Sunitinib Malate , ≥99% , 341031-54-7
Synonym(s):
N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt;SU 011248;SU 11248;SU112248
CAS NO.：341031-54-7
Empirical Formula: C26H33FN4O7
Molecular Weight: 532.57
MDL number: MFCD08282795
EINECS: 638-825-9
| Pack Size | Price | Stock | Quantity |
| 100MG | RMB84.80 | In Stock |
|
| 500MG | RMB151.20 | In Stock |
|
| 1G | RMB265.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 189-191°C |
| storage temp. | room temp |
| solubility | DMSO: >10mg/mL |
| form | powder |
| color | Orange |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | XGQXULJHBWKUJY-LYIKAWCPSA-N |
| SMILES | [C@@H](O)(C(=O)O)CC(=O)O.C(/C1NC(C)=C(C(=O)NCCN(CC)CC)C=1C)=C1/C(NC2=CC=C(F)C=C/12)=O |&1:0,r| |
| CAS DataBase Reference | 341031-54-7(CAS DataBase Reference) |
Description and Uses
Sunitinib is a small molecule inhibitor of receptor tyrosine kinases, including FLK1 (Ki = 9 nM), PDGFRβ (Ki = 8 nM), and FLT3. It is at least 10-fold selective for FLK1 and PDGFRβ over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl, and Src. Sunitinib inhibits VEGF-dependent FLK1 and PDGF-dependent PDGFRβ phosphorylation (IC50s = 10 and 10 nM, respectively) as well as phosphorylation of FLT3 and FLT3 carrying the activating internal tandem duplication mutation (FLT3-ITD; IC50s = 250 and 50 nM, respectively). It decreases VEGF- and FGF-induced proliferation of human umbilical vein endothelial cells (HUVECs; IC50s = 30 and 700 nM, respectively) and reduces tumor growth in a variety of mouse xenograft models when administered at doses ranging from 20 to 80 mg/kg per day. Formulations containing sunitinib have been used in the treatment of gastrointestinal stromal tumors and metastatic renal cell carcinoma.
Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H360-H372 |
| Precautionary statements | P201-P308+P313 |
| Hazard Codes | T |
| Risk Statements | 61-2-48/25-36/37-22-53 |
| Safety Statements | 53-22-36/37-24/25 |
| WGK Germany | 2 |
| HS Code | 29337900 |
