Ponatinib (AP24534) , ≥99% , 943319-70-8

CAS NO.：943319-70-8

Empirical Formula: C29H27F3N6O

Molecular Weight: 532.56

MDL number: MFCD17215203

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: >175°C (dec.)
• Density: 1.3
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
• form: Yellow powder.
• pka: 12.99±0.70(Predicted)
• color: Yellow
• Stability: Stable for 2 years from date? of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• CAS DataBase Reference: 943319-70-8

Description and Uses

Ponatinib (943319-70-8) is a highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM).1??Also inhibits PDGFRα, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively)2?as well as FGFR-mediated signaling (IC50<40 nM)3. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models..4

AP24534 is a novel potent, orally available small molecule multitargeted kinase inhibitor with IC50 of 0.37, 2, 1.5, 2.2, 1.1, 1and 0.24 nM for native pan-BCR-ABL, mutated form, VEGFR2, FGFR1, PDGFRα, mutant FLT3 phosphorylation and LYN.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301+H311+H331-H361d-H372
• Precautionary statements: P260-P280-P301+P310
• HS Code: 29335990
• Hazardous Substances Data: 943319-70-8(Hazardous Substances Data)