Estradiol valerate , ≥98% , 979-32-8

Synonym(s):
β-Estradiol 17-valerate;1,3,5(10)-Estratriene-3,17β-diol 17-pentanote

CAS NO.：979-32-8

Empirical Formula: C23H32O3

Molecular Weight: 356.51

MDL number: MFCD00056541

EINECS: 213-559-2

PRODUCT Properties

• Melting point: 144°C
• Boiling point: 438.83°C (rough estimate)
• Density: 1.1024 (rough estimate)
• refractive index: 1.4700 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• solubility: Practically insoluble in water, soluble in alcohol.
• pka: 10.25±0.60(Predicted)
• form: Solid
• color: White to off-white
• Merck: 13,3738
• BRN: 2480357
• InChI: InChI=1/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/s3
• InChIKey: RSEPBGGWRJCQGY-RBRWEJTLSA-N
• SMILES: C[C@]12CC[C@]3([H])C4C=CC(O)=CC=4CC[C@@]3([H])[C@]1([H])CC[C@@H]2OC(=O)CCCC |&1:1,4,15,17,21,r|

Description and Uses

Estradiol valerate (EV), sold for use by mouth under the brand name Progynova and for use by injection under the brand names Delestrogen and Progynon Depot among others, is an estrogen medication. In women, it is used in hormone therapy for menopausal symptoms and low estrogen levels, hormone therapy for transgender women, and in hormonal birth control. It is also used in the treatment of prostate cancer in men. The medication is taken by mouth or by injection into muscle or fat once every 1 to 4 weeks.

Estradiol valerate is a female hormone (estrogen). It is used to reduce symptoms of menopause which are vaginal dryness, hot flashes, and others. The symptoms of menopause manifest because the body is making less estrogen; with estradiol valerate, these symptoms are brought to the lowest minimum. This medication therapy can also produce enough estrogen in women with ovarian failure, hypogonadism and can be used by men to treat prostate cancer (palliation only).

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Warning
• Hazard statements: H351-H361fd-H362-H410
• Precautionary statements: P202-P260-P263-P264-P273-P308+P313
• Hazard Codes: T
• Risk Statements: 60-61
• Safety Statements: 53-45
• WGK Germany: 3
• RTECS: KG5793000
• HS Code: 29372390