Estrone , Analysis standard , 53-16-7
Synonym(s):
1,3,5(10)-Estratrien-3-ol-17-one;3-Hydroxy-1,3,5(10)-estratrien-17-one;Estrone;Folliculin
CAS NO.：53-16-7
Empirical Formula: C18H22O2
Molecular Weight: 270.37
MDL number: MFCD00003620
EINECS: 200-164-5
| Pack Size | Price | Stock | Quantity |
| 250MG | RMB239.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 258-260 °C(lit.) |
| alpha | 158 º (c=1, dioxane) |
| Boiling point: | 353.48°C (rough estimate) |
| Density | 1.2360 |
| refractive index | 165 ° (C=1, Dioxane) |
| Flash point: | 9℃ |
| storage temp. | room temp |
| solubility | Chloroform (Slightly), Dioxane (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Crystalline Powder or Crystals |
| pka | pKa 10.77±0.02(H2O)(Approximate) |
| color | White to almost white |
| Water Solubility | 0.03 g/L |
| Merck | 3708 |
| BRN | 1915077 |
| InChIKey | DNXHEGUUPJUMQT-CBZIJGRNSA-N |
Description and Uses
Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol. Estrone is synthesized from androstenedione by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.Serum concentrations of estrone in premenopausal women fluctuate according to the menstrual cycle and becomes the most predominant estrogen in postmenopausal women.The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.
Estrone is a metabolite of 17β-Estradiol (E888000). During the metabolism, it is in rapid equilibrium with Estriol (E888960) and 17β-Estradiol (E888000) (1). Causes the feminization of male fish at human and animal waste sites (2). This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H351-H360FD-H362 |
| Precautionary statements | P202-P260-P263-P264-P270-P308+P313 |
| Hazard Codes | T,F |
| Risk Statements | 45-60-61-64-40-63-39/23/24/25-23/24/25-11 |
| Safety Statements | 53-45-36/37-16 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | KG8575000 |
| HS Code | 29335995 |
