Home Categories API Estrone
A3951312

Estrone , >98.0% , 53-16-7

Synonym(s):
1,3,5(10)-Estratrien-3-ol-17-one;3-Hydroxy-1,3,5(10)-estratrien-17-one;Estrone;Folliculin

CAS NO.:53-16-7

Empirical Formula: C18H22O2

Molecular Weight: 270.37

MDL number: MFCD00003620

EINECS: 200-164-5

Pack Size Price Stock Quantity
1G RMB44.80 In Stock
5G RMB140.00 In Stock
25G RMB478.40 In Stock
100G RMB1442.40 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 258-260 °C(lit.)
alpha  158 º (c=1, dioxane)
Boiling point: 353.48°C (rough estimate)
Density  1.2360
refractive index  165 ° (C=1, Dioxane)
Flash point: 9℃
storage temp.  room temp
solubility  Chloroform (Slightly), Dioxane (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka pKa 10.77±0.02(H2O)(Approximate)
form  Crystalline Powder or Crystals
color  White to almost white
Water Solubility  0.03 g/L
Merck  3708
BRN  1915077
InChIKey DNXHEGUUPJUMQT-CBZIJGRNSA-N
CAS DataBase Reference 53-16-7(CAS DataBase Reference)
NIST Chemistry Reference 3-Hydroxyestra-1,3,5(10)-trien-17-one(53-16-7)
EPA Substance Registry System Estrone (53-16-7)

Description and Uses

Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol. Estrone is synthesized from androstenedione by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.Serum concentrations of estrone in premenopausal women fluctuate according to the menstrual cycle and becomes the most predominant estrogen in postmenopausal women.The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.

Estrone is a metabolite of 17β-Estradiol (E888000). During the metabolism, it is in rapid equilibrium with Estriol (E888960) and 17β-Estradiol (E888000) (1). Causes the feminization of male fish at human and animal waste sites (2). This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H351-H360FD-H362
Precautionary statements  P202-P260-P263-P264-P270-P308+P313
Hazard Codes  T,F
Risk Statements  45-60-61-64-40-63-39/23/24/25-23/24/25-11
Safety Statements  53-45-36/37-16
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  KG8575000
HS Code  29335995
Hazardous Substances Data 53-16-7(Hazardous Substances Data)

RELATED PRODUCTS