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A3405512

Cynarin , ≥98%(HPLC) , 30964-13-7

Synonym(s):
Cynarin;1,3-Dicaffeoylquinic acid;1,5-Dicaffeoylquinic acid;Cynarine;1,5-DQA

CAS NO.:30964-13-7

Empirical Formula: C25H24O12

Molecular Weight: 516.45

MDL number: MFCD00075714

EINECS: 214-655-7

Pack Size Price Stock Quantity
5MG RMB559.20 In Stock
25MG RMB1903.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 225-227°
alpha  D25 -59° (c = 2 in methanol)
Boiling point: 819.9±65.0 °C(Predicted)
Density  1?+-.0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,2-8°C
solubility  methanol: soluble5mg/mL, clear, light yellow to yellow
pka 2.58±0.50(Predicted)
form  Solid
color  faint yellow to yellow
Stability: Hygroscopic
LogP 1.640 (est)
CAS DataBase Reference 30964-13-7(CAS DataBase Reference)

Description and Uses

1,3-Dicaffeoylquinic acid is a polyphenol that has been found in C. scolymus. It decreases the expression and protein levels of inducible nitric oxide synthase (iNOS) when used at a concentration of 10 μM in human coronary artery smooth muscle cells (HCASMCs) treated with a cytokine mixture. 1,3-Dicaffeoylquinic acid decreases protein levels of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16F1 murine melanocytes. It inhibits melanogenesis in B16F1 cells and decreases tyrosinase activity in cell lysates when used at a concentration of 25 μM. 1,3-Dicaffeoylquinic acid (20 and 40 μM) reduces triglyceride levels in sodium oleate-induced hyperlipidemic HepG2 cells compared to hyperlipidemic control cells.

Cynarin is used on MDR cells in anti-cancer therapy as an inhibitor of P-glycoprotein-mediated transport.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
Safety Statements  24/25
WGK Germany  3
HS Code  29182900

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