Cynarin , ≥98%(HPLC) , 30964-13-7
Synonym(s):
Cynarin;1,3-Dicaffeoylquinic acid;1,5-Dicaffeoylquinic acid;Cynarine;1,5-DQA
CAS NO.：30964-13-7
Empirical Formula: C25H24O12
Molecular Weight: 516.45
MDL number: MFCD00075714
EINECS: 214-655-7
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB559.20 | In Stock |
|
| 25MG | RMB1903.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 225-227° |
| alpha | D25 -59° (c = 2 in methanol) |
| Boiling point: | 819.9±65.0 °C(Predicted) |
| Density | 1?+-.0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | methanol: soluble5mg/mL, clear, light yellow to yellow |
| pka | 2.58±0.50(Predicted) |
| form | Solid |
| color | faint yellow to yellow |
| Stability: | Hygroscopic |
| LogP | 1.640 (est) |
Description and Uses
1,3-Dicaffeoylquinic acid is a polyphenol that has been found in C. scolymus. It decreases the expression and protein levels of inducible nitric oxide synthase (iNOS) when used at a concentration of 10 μM in human coronary artery smooth muscle cells (HCASMCs) treated with a cytokine mixture. 1,3-Dicaffeoylquinic acid decreases protein levels of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16F1 murine melanocytes. It inhibits melanogenesis in B16F1 cells and decreases tyrosinase activity in cell lysates when used at a concentration of 25 μM. 1,3-Dicaffeoylquinic acid (20 and 40 μM) reduces triglyceride levels in sodium oleate-induced hyperlipidemic HepG2 cells compared to hyperlipidemic control cells.
Cynarin is used on MDR cells in anti-cancer therapy as an inhibitor of P-glycoprotein-mediated transport.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29182900 |
