3,5-Dibromopyridine , 98% , 625-92-3

CAS NO.：625-92-3

Empirical Formula: C5H3Br2N

Molecular Weight: 236.89

MDL number: MFCD00014634

EINECS: 210-916-4

PRODUCT Properties

• Melting point: 110-115 °C (lit.)
• Boiling point: 222 °C
• Density: 2.0383 (rough estimate)
• refractive index: 1.5800 (estimate)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMSO (Slightly, Heated), Methanol (Slightly)
• pka: 0.52±0.20(Predicted)
• form: Needle-Like Crystals
• color: White to light beige
• Water Solubility: Soluble in Chloroform and Methanol. Insoluble in water.
• BRN: 108477
• InChIKey: SOSPMXMEOFGPIM-UHFFFAOYSA-N

Description and Uses

3-Acetylamino-5-ethoxypyridine was prepared by converting 3, 5-dibromopyridine with sodium ethylate into 3-bromo-5-ethoxypyridine, allowing this substance to interact with ammonia and acetylating the aminoethoxypyridine thus formed with acetic anhydride. Lithiation of 3, 5-dibromopyridine with LDA and subsequent reaction with electrophiles provided 4-alkyl-3, 5-dibromopyridines 2 in high yield. Ligand was prepared by a Pd(0)-catalyzed cross-coupling reaction of 3,5-dibromopyridine and 5-tributylstannyl-3,3?-bipyridine. The synthesis of 3, 5-bis (2-indolyl) pyridine and 3-[(2-indolyl)-5-phenyl] pyridine derivatives as includes Stille or Suzuki type reactions, which were realized on the 3,5-dibromopyridine.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39
• RIDADR: UN2811
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 29333999