Home Categories API Demeclocycline hydrochloride
A3222012

Demeclocycline hydrochloride , ≥90%(HPLC) , 64-73-3

Synonym(s):
7-Chloro-6-demethyltetracycline hydrochloride;Chlorodemethyltetracycline hydrochloride;Demeclocycline hydrochloride;Demethylchlorotetracycline hydrochloride

CAS NO.:64-73-3

Empirical Formula: C21H21ClN2O8.ClH

Molecular Weight: 501.32

MDL number: MFCD00864922

EINECS: 200-592-2

Pack Size Price Stock Quantity
250MG RMB302.40 In Stock
1G RMB851.20 In Stock
5G RMB4479.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >245°C (dec.)
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  H2O: 20 mg/mL, clear, very deep greenish yellow
form  powder
pka pKa 3.3 (Uncertain)
color  Light Yellow to Yellow
Water Solubility  Soluble in water.
Merck  13,2905
BRN  5705221
InChIKey GVSJQNRGSCOSNJ-KBHRXELFSA-N

Description and Uses

Demeclocycline lacks the C-6-methyl of tetracycline and is produced by a genetically altered strain of Streptomyces aureofaciens. Because it is a secondary alcohol, it is more chemically stable than tetracycline against dehydration. Food and milk co-consumption decrease absorption by half, although it is 60 to 80% absorbed by fasting adults. It is the tetracycline most highly associated with phototoxicity and has been shown to produce dose-dependent, reversible diabetes insipidus with extended use.

Antibacterial;Ribosomal protein synthesis inhibitor

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335-H341
Precautionary statements  P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313
Hazard Codes  Xi
Risk Statements  43
Safety Statements  36/37
WGK Germany  2
RTECS  QI7700000
8-10-21
HS Code  29413020
Toxicity LD50 orally in rats: 2372 mg/kg (Goldenthal)

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