Demeclocycline hydrochloride , Analysis standard , 64-73-3

Synonym(s):
7-Chloro-6-demethyltetracycline hydrochloride;Chlorodemethyltetracycline hydrochloride;Demeclocycline hydrochloride;Demethylchlorotetracycline hydrochloride

CAS NO.：64-73-3

Empirical Formula: C21H21ClN2O8.ClH

Molecular Weight: 501.32

MDL number: MFCD00864922

EINECS: 200-592-2

PRODUCT Properties

• Melting point: >245°C (dec.)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: H₂O: 20 mg/mL, clear, very deep greenish yellow
• form: powder
• pka: pKa 3.3 (Uncertain)
• color: Light Yellow to Yellow
• Water Solubility: Soluble in water.
• Merck: 13,2905
• BRN: 5705221
• InChIKey: GVSJQNRGSCOSNJ-KBHRXELFSA-N
• CAS DataBase Reference: 64-73-3(CAS DataBase Reference)
• EPA Substance Registry System: 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)- (64-73-3)

Description and Uses

Demeclocycline lacks the C-6-methyl of tetracycline and is produced by a genetically altered strain of Streptomyces aureofaciens. Because it is a secondary alcohol, it is more chemically stable than tetracycline against dehydration. Food and milk co-consumption decrease absorption by half, although it is 60 to 80% absorbed by fasting adults. It is the tetracycline most highly associated with phototoxicity and has been shown to produce dose-dependent, reversible diabetes insipidus with extended use.

Antibacterial;Ribosomal protein synthesis inhibitor

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302+H312+H332-H315-H319-H335-H341
• Precautionary statements: P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313
• Hazard Codes: Xi
• Risk Statements: 43
• Safety Statements: 36/37
• WGK Germany: 2
• RTECS: QI7700000
• F: 8-10-21
• HS Code: 29413020
• Toxicity: LD50 orally in rats: 2372 mg/kg (Goldenthal)