A3221912
Demeclocycline hydrochloride , Analysis standard , 64-73-3
Synonym(s):
7-Chloro-6-demethyltetracycline hydrochloride;Chlorodemethyltetracycline hydrochloride;Demeclocycline hydrochloride;Demethylchlorotetracycline hydrochloride
CAS NO.：64-73-3
Empirical Formula: C21H21ClN2O8.ClH
Molecular Weight: 501.32
MDL number: MFCD00864922
EINECS: 200-592-2
| Pack Size | Price | Stock | Quantity |
| 100MG | RMB576.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >245°C (dec.) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | H2O: 20 mg/mL, clear, very deep greenish yellow |
| form | powder |
| pka | pKa 3.3 (Uncertain) |
| color | Light Yellow to Yellow |
| Water Solubility | Soluble in water. |
| Merck | 13,2905 |
| BRN | 5705221 |
| InChIKey | GVSJQNRGSCOSNJ-KBHRXELFSA-N |
Description and Uses
Demeclocycline lacks the C-6-methyl of tetracycline and is produced by a genetically altered strain of Streptomyces aureofaciens. Because it is a secondary alcohol, it is more chemically stable than tetracycline against dehydration. Food and milk co-consumption decrease absorption by half, although it is 60 to 80% absorbed by fasting adults. It is the tetracycline most highly associated with phototoxicity and has been shown to produce dose-dependent, reversible diabetes insipidus with extended use.
Antibacterial;Ribosomal protein synthesis inhibitor
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335-H341 |
| Precautionary statements | P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313 |
| Hazard Codes | Xi |
| Risk Statements | 43 |
| Safety Statements | 36/37 |
| WGK Germany | 2 |
| RTECS | QI7700000 |
| F | 8-10-21 |
| HS Code | 29413020 |
| Toxicity | LD50 orally in rats: 2372 mg/kg (Goldenthal) |
